Engineered Nanoparticle Aerosol Foam Formulation for Skin Diseases
نویسندگان
چکیده
The objective of the work is to formulate, optimize and evaluate “Itraconazole nanosuspension as aerosol foam formulation” for the treatment of skin diseases such as Cellulitis, Erysipelas, Impeigo and Blastomycosis, Histoplasmosis, Onchomycosis, etc. The solubility of poorly soluble itraconazole can be improved through nanosuspension process and also the absorption rate and bioavailability of drug can be enhanced by means of aerosol foam dispersion at the site of application.
منابع مشابه
Enhanced vasoconstrictor potency of the fixed combination calcipotriol plus betamethasone dipropionate in an innovative aerosol foam formulation vs. other corticosteroid psoriasis treatments
BACKGROUND An aerosol foam formulation of fixed combination calcipotriol 50 μg/g (Cal) and betamethasone 0.5 mg/g (as dipropionate; BD) has been developed for psoriasis vulgaris treatment. OBJECTIVE To compare Cal/BD aerosol foam pharmacodynamic activity with Cal/BD ointment and with other topical corticosteroids of different potencies by assessing vasoconstrictor potential. METHODS A Phase...
متن کاملSupersaturation of Calcipotriene and Betamethasone Dipropionate in a Novel Aerosol Foam Formulation for Topical Treatment of Psoriasis Provides Enhanced Bioavailability of the Active Ingredients
INTRODUCTION Previous studies have demonstrated the superior efficacy of a novel aerosol foam formulation of fixed combination calcipotriene 0.005% (Cal) and betamethasone dipropionate 0.064% (BD), compared with the ointment formulation. The aim of this study is to ascertain whether enhanced bioavailability of the active ingredients due to supersaturation and/or occlusive properties can explain...
متن کاملEfficacy of an Innovative Aerosol Foam Formulation of Fixed Combination Calcipotriol plus Betamethasone Dipropionate in Patients with Psoriasis Vulgaris
BACKGROUND AND OBJECTIVE The antipsoriatic effect of an innovative aerosol foam formulation of fixed combination calcipotriol 50 μg/g (as hydrate; Cal) and betamethasone 0.5 mg/g (as dipropionate; BD) was explored in order to compare the effect with that of the first-line treatment Cal/BD ointment. METHODS This was a Phase IIa, single-centre, investigator-blinded, exploratory study, with intr...
متن کاملDermal transfer of chlorpyrifos residues from residential surfaces: comparison of hand press, hand drag, wipe, and polyurethane foam roller measurements after broadcast and aerosol pesticide applications.
Indoor residential pesticide applications present the potential for human exposures, particularly for small children. Personal contact with target and nontarget surfaces can result in transfer of pesticides to the skin, but the magnitude of such transfer is uncertain. This research compared surface sampling techniques [wipe and polyurethane foam (PUF) roller] with the removal ability of human s...
متن کاملOptimizing Anti-Inflammatory and Immunomodulatory Effects of Corticosteroid and Vitamin D Analogue Fixed-Dose Combination Therapy
Fixed-dose combination topical therapy with corticosteroid and vitamin D analog provides effective treatment and possible long-term management of psoriasis. The anti-inflammatory and immunomodulatory effects of corticosteroids and vitamin D analogs in treating psoriasis are well investigated; their complementary effects lead to the disruption of the inflammatory feedback loop underlying psorias...
متن کامل